Liposomes are artificial vesicles with a double lipid layer. They represent one of the most promising carriers not only for biologically active compounds in cosmetic and pharmaceutical applications, but also for substances used in the food industry (e.g., antioxidants, flavors, antimicrobials) that are incorporated into liposomes in order to make them stable.
The liposomes’ particle size, as well as surface charge, affect the encapsulation capacity and the uptake from the target cells, especially if they are used as drug delivery systems. Any modification of the liposome surface can also be monitored via measurement of the zeta potential.
Knowledge of the liposome size as well as liposome zeta potential helps in the characterization of the special coatings and in the controlling of aggregation, fusion, and precipitation, which are important factors affecting the stability of liposomal formulations and the in-vivo behavior of liposomes.